ACT 3

Reducing the prevalence of tuberculosis in a highly endemic setting by community-wide active case finding

STUDY SITE: Ca Mau province

COMPLETED: 2019

PROJECT IMPLEMENTERS: National Lung Hospital / National TB Program

FUNDED BY: National Health and Medical Research Council (NHMRC)

CORE STAKEHOLDER: Ca Mau Center for Social Disease Prevention

PRINCIPAL INVESTIGATOR: Professor Guy Marks, The University of New South Wales and the Woolcock Institute of Medical Research

VIETNAMESE PRINCIPAL INVESTIGATOR: Associate Professor Nguyen Viet Nhung, National Lung Hospital

PRIMARY OBJECTIVE: To determine the effectiveness of community-wide screening for tuberculosis using the Xpert MTB/RIF platform annually for four years, compared with usual TB control practices, on the TB prevalence in a rural province of Vietnam.

This study was registered as a clinical trial under number: ACTRN12614000372684

OUTCOMES: Analysis of this study is currently underway.

Publications

A comparison of digital chest radiography and Xpert MTB/RIF in active case finding for tuberculosis, The International Journal of Tuberculosis and Lung Disease
A Transcriptional Blood Signature Distinguishes Early Tuberculosis Disease from Latent Tuberculosis Infection and Uninfected Individuals in a Vietnamese Cohort, The Journal of Infection
Effect of two alternative methods of pooling sputum prior to testing for tuberculosis with genexpert MTB/RIF, BMC Infectious Diseases
Community-wide Screening for Tuberculosis in a High-Prevalence Setting, New England Journal of Medicine