ACT 4

Enhancing the public health impact of latent tuberculosis infection diagnosis and treatment: A pragmatic cluster randomised trial

STUDY SITES: Quang Nam and Da Nang province

COMPLETED: March 2019

PROJECT IMPLEMENTERS: National Lung Hospital / National TB Program

PARTICIPATING COUNTRIES: Canada, Benin, Ghana, Brazil, Indonesia, Vietnam

FUNDED BY: Canadian Institute of Health Research (CIHR)

CORE STAKEHOLDERS: Da Nang Lung Hospital and Quang Nam Pham Ngoc Thach Hospital

PRINCIPAL INVESTIGATOR: Professor Greg Fox, The University of Sydney and the Woolcock Institute of Medical Research

VIETNAMESE PRINCIPAL INVESTIGATOR: Associate Professor Nguyen Viet Nhung, National Lung Hospital

PRIMARY OBJECTIVE: To estimate the increase in number of close contacts (of pulmonary tuberculosis patients) who are identified, investigated, initiated, and completed latent tuberculosis infection (LTBI) therapy. The intervention is a standardised public health evaluation (Cascade analysis), with use of operational modeling analysis to select effective interventions from a "public health toolkit".

This study was registered as a clinical trial under number: NCT02810678

OUTCOMES: Analysis of this study is currently underway.

Publications

• Effectiveness and cost-effectiveness of a health systems intervention for latent tuberculosis infection management (ACT4): a cluster-randomised trial, The Lancet Public Health
  

• Resource implications of the latent tuberculosis cascade of care: a time and motion study in five countries, BMC Health Services Research