2R-Squared

Higher dose rifampin for two months vs standard dose rifampin for latent tuberculosis: A 3-arm randomised trial

rifampin_trial

STUDY SITES: Ho Chi Minh City and Hanoi

TIMELINE: 2020 - 2023

PROJECT IMPLEMENTER: National TB Program

FUNDED BY: Canadian Institutes of Health Research

CORE STAKEHOLDERS: National Lung Hospital, Pham Ngoc Thach Hospital (Ho Chi Minh City)

OBJECTIVES:

  1. Compare completion of three different regimens of daily self-administered oral rifampin: (1) Standard = 10 mg/kg/day for 4 months (4R10), or (2) 20 mg/kg/day for 2 months (2R20), or, (3) 30 mg/kg/day for 2 months (2R30).

  2. Compare the three regimens in terms of their rate of Grade 3 to 5 adverse events (AE) that result in permanent discontinuation of study drug and are considered probably or possibly related to the study drug by an independent 3-member adjudication panel blinded to study arm (safety).