Host genetic susceptibility to tuberculosis study

STUDY SITES: Hanoi Capital, Vinh Phuc and Hoa Binh Provinces


PROJECT IMPLEMENTER: National Lung Hospital

FUNDED BY: The Centenary Institute

CORE STAKEHOLDERS: The National Lung Hospital in Hanoi, and provincial Lung Hospitals in Hanoi, Vinh Phuc and Hoa Binh.

PRIMARY OBJECTIVE: The GenTB project aimed to compare genetic factors among patients diagnosed with tuberculosis to healthy control subjects. The study aimed to identify specific factors associated with increased susceptibility to pulmonary and extra-pulmonary tuberculosis.

OUTCOMES: Variants of a gene were associated with increased susceptibility to both pulmonary and extra-pulmonary tuberculosis in the Vietnamese. Genetic variants in this gene may influence the responses of immune cells (called macrophages) to infection with the bacteria that cause tuberculosis. Further research is required to establish the mechanism by which this gene influences immunity to tuberculosis infection.