Combating the emergence and spread of antimicrobial resistant infectious diseases in Vietnam: the V-RESIST study


STUDY SITES: Hanoi, Thanh Hoa, An Giang and Ca Mau

TIMELINE: Q4/2018 – Q3/2021

PROJECT IMPLEMENTER: National Institute of Hygiene and Epidemiology   

FUNDED BY: Woolcock Institute of Medical Research


  1. Vietnam Administrative Medical Service – Ministry of Health

  2. Health Strategy and Health Policy Institute

  3. National Lung Hospital

  4. Hanoi University of Pharmacy

  5. University of Medicine and Pharmacy, Ho Chi Minh city

  6. Pasteur Institute in Ho Chi Minh city

STUDY OBJECTIVE: The overall aim of this project is to develop, implement and evaluate the effectiveness of a complex health system intervention to reduce the emergence of antimicrobial resistance (AMR) in Vietnam.       


  1. Characterise health system barriers to appropriate antibiotic use and AMR control 

  2. Evaluate the effectiveness of a community-based programme to reduce inappropriate use of antimicrobials, in the public and private sectors 

  3. Assess the cost-effectiveness of the interventions implemented

  4. Building capacity for healthcare staff


The research consists of 3 phases.

Phase 1 (Q4/2018 – Q3/2019): Conduct baseline evaluation of AMR to develop feasible and effective interventions in phase 2.

Phase 2 (Q2/2019 – Q2/2021): Cluster randomised trial evaluating the effectiveness of community-based interventions to reduce inappropriate use of antimicrobials in the public and private sectors.

Phase 3 (Q1/2020 – Q2/2021): The economic evaluation of this study will comprise a modelled evaluation of long-term costs and cost-effectiveness of the interventions using Disability Adjusted Life Years (DALYs). This study will generate estimates of the cost of current antibiotic use, the predicted health system costs associated with AMR over the coming years and the social return on investment of interventions in lowering this economic burden and health costs reports.

All three phases of this study will contribute to research capacity building by training study staff, master and PhD level trainees, and post-doctors.